The Quakers improved to 2-0 while the Panthers dropped to 1-1.
The match was tied 0-0 at halftime. Matthew Fritts netted an unassisted goal to put the home team ahead, 1-0, in the 51st minute.
On Guidino's game-winner, Grieco slipped a pass through the LaGrange defense that left Gudino one-on-one with Aycock. The Panther goalkeeper had no chance to stop Gudino's shot from 10 yards out.
Guilford had the edge in shots (13-5) and corner kicks (7-4). Zach Vampen made two saves for the Quakers and earned the win. Aycock stopped seven shots in the loss.
The Quakers return to action on Wednesday (9/5) vs. Methodist University. The Guilford home opener begins at 7:30 p.m.